As men age, their testosterone levels naturally decrease, which can lead to a variety of symptoms such as decreased energy, decreased muscle mass, and decreased libido. Testosterone Replacement Therapy (TRT) is a treatment option that can alleviate these symptoms and improve quality of life. However, TRT can also lead to decreased fertility and testicular shrinkage. These are serious considerations for younger men who wish to start or expand their families. Human Chorionic Gonadotropin (HCG) is a hormone that can be used in combination with TRT to alleviate these negative side effects. In this article, we will explore the benefits and considerations of combining HCG with TRT.


HCG is a hormone that mimics luteinizing hormone (LH) in the body. LH is responsible for signaling the testicles to produce testosterone, as well as sperm production. When a man is on TRT, the exogenous testosterone can send a signal to the brain to stop producing LH, which can lead to decreased fertility and testicular shrinkage. By taking HCG alongside TRT, the signal to produce LH is maintained, which can lead to improved fertility and testicular health.

Another benefit of HCG is the preservation of secondary sexual characteristics. TRT alone can lead to testicular shrinkage, decreased libido, and decreased sperm production. By taking HCG alongside TRT, these symptoms can be alleviated, thus improving overall quality of life.


One consideration when combining HCG with TRT is the potential for mood swings and acne. HCG can cause an increase in estrogen levels, which can lead to mood changes and acne. These side effects can be managed with careful monitoring and adjustment of dosage.

Another consideration is the cost of HCG. In the United States, HCG is not covered by insurance for this purpose, and can be quite costly. Additionally, the cost of regular blood work to monitor hormone levels can add up.


In conclusion, combining HCG with TRT can be a beneficial treatment option for men who wish to improve their fertility and maintain overall testicular health. However, careful consideration of potential side effects and costs is necessary. If you are considering this treatment option, it is important to speak with a healthcare provider who is knowledgeable in hormone therapy to determine the best course of action for your individual needs and goals.